Forward-Time Population Genetics Simulations

, ,

Wysyłka: Niedostępna
Sugerowana cena detaliczna 336,00 PLN
Nasza cena: 317,00 PLN
Oszczędzasz 5%
Dodaj do Schowka
Zaloguj się
Przypomnij hasło
×
×
Darmowa dostawa
Oferujemy szeroki asortyment - ponad 120 tys. produktów
Dysponujemy solidną wiedzą - działamy już 11 lat
Dbamy o wybór najcenniejszych tytułów

Opis: Forward-Time Population Genetics Simulations - Christopher I. Amos, Marek Kimmel, Bo Peng

The rapid increase of the power of personal computers has led to the use of serious simulation programs such as easy POP in genetic studies. This book summarizes recent advances in forward-time simulation methods and demonstrates their applications in population genetics and genetic epidemiology. The authors introduce commonly used forward-time population genetics simulation methods, including some new methods, and introduce a forward-time population genetics simulation environment, simuPOP, as a powerful and flexible tool to implement these simulations. Researchers and students in population and statistical genetics will find this book useful.Preface ix Acknowledgments xiii List of examples xxiii 1. Basic concepts and models 1 1.1 Biological and genetic concepts 2 1.2 Population and evolutionary genetics 6 1.3 Statistical genetics and genetic epidemiology 17 2. Simulation of population genetics models 25 2.1 Random genetic drift 25 2.2 Demographic models 29 2.3 Mutation 31 2.4 Migration 34 2.5 Recombination and linkage disequilibrium 36 2.6 Natural selection 37 2.7 Genealogy of forward-time simulations 41 3. Ascertainment bias in population genetics 47 3.1 Introduction 47 3.2 Methods 49 3.3 Results 54 3.4 Discussion and Conclusions 58 4. Observing properties of evolving populations 63 4.1 Introduction 64 4.2 Simulation of the evolution of allele spectra 66 4.3 Extensions to the basic model 78 5. Simulating populations with complex human diseases 89 5.1 Introduction 89 5.2 Controlling disease allele frequencies at the present generation 91 5.3 Forward-time simulation of realistic samples 102 5.4 Discussion 119 6. Nonrandom mating and its applications 125 6.1 Assortative mating 126 6.2 More complex non-random mating schemes 132 6.3 Hetergeneous mating schemes 140 6.4 Simulation of age structured populations 145 Appendix: Forward-time simulations using stimulPOP 157 A.1 Introduction 157 A.2 Population 160 A.3 Operators 172 A.4 Evolve on or more populations 181 A.5 A complete stimuPOP script 185


Szczegóły: Forward-Time Population Genetics Simulations - Christopher I. Amos, Marek Kimmel, Bo Peng

Tytuł: Forward-Time Population Genetics Simulations
Autor: Christopher I. Amos, Marek Kimmel, Bo Peng
Producent: John Wiley
ISBN: 9780470503485
Rok produkcji: 2010
Ilość stron: 256
Oprawa: Miękka
Waga: 0.41 kg


Recenzje: Forward-Time Population Genetics Simulations - Christopher I. Amos, Marek Kimmel, Bo Peng

Zaloguj się
Przypomnij hasło
×
×

Forward-Time Population Genetics Simulations

, ,

The rapid increase of the power of personal computers has led to the use of serious simulation programs such as easy POP in genetic studies. This book summarizes recent advances in forward-time simulation methods and demonstrates their applications in population genetics and genetic epidemiology. The authors introduce commonly used forward-time population genetics simulation methods, including some new methods, and introduce a forward-time population genetics simulation environment, simuPOP, as a powerful and flexible tool to implement these simulations. Researchers and students in population and statistical genetics will find this book useful.Preface ix Acknowledgments xiii List of examples xxiii 1. Basic concepts and models 1 1.1 Biological and genetic concepts 2 1.2 Population and evolutionary genetics 6 1.3 Statistical genetics and genetic epidemiology 17 2. Simulation of population genetics models 25 2.1 Random genetic drift 25 2.2 Demographic models 29 2.3 Mutation 31 2.4 Migration 34 2.5 Recombination and linkage disequilibrium 36 2.6 Natural selection 37 2.7 Genealogy of forward-time simulations 41 3. Ascertainment bias in population genetics 47 3.1 Introduction 47 3.2 Methods 49 3.3 Results 54 3.4 Discussion and Conclusions 58 4. Observing properties of evolving populations 63 4.1 Introduction 64 4.2 Simulation of the evolution of allele spectra 66 4.3 Extensions to the basic model 78 5. Simulating populations with complex human diseases 89 5.1 Introduction 89 5.2 Controlling disease allele frequencies at the present generation 91 5.3 Forward-time simulation of realistic samples 102 5.4 Discussion 119 6. Nonrandom mating and its applications 125 6.1 Assortative mating 126 6.2 More complex non-random mating schemes 132 6.3 Hetergeneous mating schemes 140 6.4 Simulation of age structured populations 145 Appendix: Forward-time simulations using stimulPOP 157 A.1 Introduction 157 A.2 Population 160 A.3 Operators 172 A.4 Evolve on or more populations 181 A.5 A complete stimuPOP script 185

Powiadom o dostępności
Podaj swój e-mail a zostaniesz poinformowany jak tylko pozycja będzie dostępna.
×
Cena 336,00 PLN
Nasza cena 317,00 PLN
Oszczędzasz 5%
Wysyłka: Niedostępna
Dodaj do Schowka
Zaloguj się
Przypomnij hasło
×
×

Darmowa dostawa
Zaloguj się
Przypomnij hasło
×
×
Dodane do koszyka
×