Molecular Approaches to Controlling Cancer

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Opis: Molecular Approaches to Controlling Cancer - Stillman

The 2005 Cold Spring Harbor Symposium on Quantitative Biology focused on molecular strategies aimed at understanding and controlling the cancerous state. The resulting volume, with contributions from the world's leading laboratories, covers many aspects of cancer genetics, including DNA repair, telomeres, animal models, stem cells, and therapeutic approaches.Symposium Participants Dedication Foreword Cancer Genetics and Genomes Oncogenes Come of Age H. Varmus, W. Pao, K. Politi, K. Podsypanina, and Y.-C.N. Du Common and Contrasting Genomic Profiles among the Major Human Lung Cancer Subtypes G. Tonon, C. Brennan, A. Protopopov, G. Maulik, B. Feng, Y. Zhang, D.B. Khatry, M.J. You, A.J. Aguirre, E.S. Martin, Z. Yang, H. Ji, L. Chin, K.-K. Wong, and R.A. DePinho Lineage Addiction in Human Cancer: Lessons from Integrated Genomics L.A. Garraway, B.A. Weir, X. Zhao, H. Widlund, R. Beroukhim, A. Berger, D. Rimm, M.A. Rubin, D.E. Fisher, M.L. Meyerson, and W.R. Sellers Polygenic Inherited Predisposition to Breast Cancer B.A.J. Ponder, A. Antoniou, A. Dunning, D.F. Easton, and P.D.P. Pharoah Somatic Mutations in Human Cancer: Insights from Resequencing the Protein Kinase Gene Family P.A. Futreal, R. Wooster, and M.R. Stratton High-Resolution ROMA CGH and FISH Analysis of Aneuploid and Diploid Breast Tumors J. Hicks, L. Muthuswamy, A. Krasnitz, N. Navin, M. Riggs, V. Grubor, D. Esposito, J. Alexander, J. Troge, M. Wigler, S. Maner, P. Lundin, and A. Zetterberg Ductal Pancreatic Cancer in Humans and Mice D.A. Tuveson and S.R. Hingorani Detection of Oncogenic Mutations in the EGFR Gene in Lung Adenocarcinoma with Differential Sensitivity to EGFR Tyrosine Kinase Inhibitors R.K. Thomas, H. Greulich, Y. Yuza, J.C. Lee, T. Tengs, W. Feng, T.-H. Chen, E. Nickerson, J. Simons, M. Egholm, J.M. Rothberg, W.R. Sellers, and M.L. Meyerson Two Decades of Cancer Genetics: From Specificity to Pleiotropic Networks S. Grisendi and P.P. Pandolfi DNA Damage Response Abnormalities of the Inactive X Chromosome Are a Common Feature of BRCA1 Mutant and Sporadic Basal-like Breast Cancer S. Ganesan, A.L. Richardson, Z.C. Wang, J.D. Iglehart, A. Miron, J. Feunteun, D. Silver, and D.M. Livingston The ATM-dependent DNA Damage Signaling Pathway R. Kitagawa and M.B. Kastan Single-Nucleotide Polymorphisms in the p53 Pathway S.L. Harris, G. Gil, W. Hu, H. Robins, E. Bond, K. Hirshfield, Z. Feng, X. Yu, A.K. Teresky, G. Bond, and A.J. Levine Transcriptional Regulation by p53 and p73 M. Lokshin, T. Tanaka, and C. Prives p53-Dependent and -Independent Functions of the Arf Tumor Suppressor C.J. Sherr, D. Bertwistle, W. den Besten, M.-L. Kuo, M. Sugimoto, K. Tago, R.T. Williams, F. Zindy, and M.F. Roussel Exploiting the DNA Repair Defect in BRCA Mutant Cells in the Design of New Therapeutic Strategies for Cancer A.N.J. Tutt, C.J. Lord, N. McCabe, H. Farmer, N. Turner, N.M. Martin, S.P. Jackson, G.C.M. Smith, and A. Ashworth Cancer Biology and Stem Cells Identifying Site-specific Metastasis Genes and Functions G.P. Gupta, A.J. Minn, Y. Kang, P.M. Siegel, I. Serganova, C. Cord f3;n-Cardo, A.B. Olshen, W.L. Gerald, and J. Massagu e9; The von Hippel-Lindau Tumor Suppressor Protein: Roles in Cancer and Oxygen Sensing W.G. Kaelin, Jr. The Src Substrate Tks5, Podosomes (Invadopodia), and Cancer Cell Invasion S.A. Courtneidge, E.F. Azucena, Jr., I. Pass, D.F. Seals, and L. Tesfay Modeling Neurofibromatosis Type 1 Tumors in the Mouse for Therapeutic Intervention L.F. Parada, C.-H. Kwon, and Y. Zhu Stem Cell Self-Renewal and Cancer Cell Proliferation Are Regulated by Common Networks That Balance the Activation of Proto-oncogenes and Tumor Suppressors R. Pardal, A.V. Molofsky, S. He, and S.J. Morrison Prostate Stem Cells and Prostate Cancer D.A. Lawson, L. Xin, R. Lukacs, Q. Xu, D. Cheng, and O.N. Witte Telomeres, Senescence, and Aging Telomere-related Genome Instability in Cancer T. de Lange Telomerase and Cancer Stem Cells M. Armanios and C.W. Greider Regulation of Telomerase by Human Papillomaviruses D.A. Galloway, L.C. Gewin, H. Myers, W. Luo, C. Grandori, R.A. Katzenellenbogen, and J.K. McDougall Animal Models for Cancer Genomic Progression in Mouse Models for Liver Tumors A.D. Tward, K.D. Jones, S. Yant, M.A. Kay, R. Wang, and J.M. Bishop Genotype-Phenotype Relationships in a Mouse Model for Human Small-Cell Lung Cancer J. Calb f3;, R. Meuwissen, E. van Montfort, O. van Tellingen, and A. Berns Cell Cycle and Cancer: Genetic Analysis of the Role of Cyclin-dependent Kinases M. Barbacid, S. Ortega, R. Sotillo, J. Odajima, A. Mart ed;n, D. Santamar ed;a, P. Dubus, and M. Malumbres Mouse Models of Human Non-Small-Cell Lung Cancer: Raising the Bar C.F.B. Kim, E.L. Jackson, D.G. Kirsch, J. Grimm, A.T. Shaw, K. Lane, J. Kissil, K.P. Olive, A. Sweet-Cordero, R. Weissleder, and T. Jacks Generation and Analysis of Genetically Defined Liver Carcinomas Derived from Bipotential Liver Progenitors L. Zender, W. Xue, C. Cord f3;n-Cardo, G.J. Hannon, R. Lucito, S. Powers, P. Flemming, M.S. Spector, and S.W. Lowe Oncogene-dependent Tumor Suppression: Using the Dark Side of the Force for Cancer Therapy G.I. Evan, M. Christophorou, E.A. Lawlor, I. Ringshausen, J. Prescott, T. Dansen, A. Finch, C. Martins, and D. Murphy Chromosomal Translocation Engineering to Recapitulate Primary Events of Human Cancer A. Forster, R. Pannell, L. Drynan, F. Cano, N. Chan, R. Codrington, A. Daser, N. Lobato, M. Metzler, C.-H. Nam, S. Rodriguez, T. Tanaka, and T. Rabbitts Deciphering Cancer Complexities in Genetically Engineered Mice K. Simin, R. Hill, Y. Song, Q. Zhang, R. Bash, R.D. Cardiff, C. Yin, A. Xiao, K. McCarthy, and T. Van Dyke Gene Expression and Cancer The Evolving Portrait of Cancer Metastasis P.B. Gupta, S. Mani, J. Yang, K. Hartwell, and R.A. Weinberg Genomic Binding and Transcriptional Regulation by the Drosophila Myc and Mnt Transcription Factors A. Orian, S.S. Grewal, P.S. Knoepfler, B.A. Edgar, S.M. Parkhurst, and R.N. Eisenman Regulation of the Arf/p53 Tumor Surveillance Network by E2F P.J. Iaquinta, A. Aslanian, and J.A. Lees Genetic and Epigenetic Changes in Mammary Epithelial Cells Identify a Subpopulation of Cells Involved in Early Carcinogenesis H. Berman, J. Zhang, Y.G. Crawford, M.L. Gauthier, C.A. Fordyce, K. McDermott, M. Sigaroudinia, K. Kozakiewicz, and T.D. Tlsty Epigenetic Changes in Cancer and Preneoplasia J.G. Herman A Genetic Approach to Cancer Epigenetics A.P. Feinberg Tumor Responses to Microenvironment Microenvironmental Regulators of Tissue Structure and Function Also Regulate Tumor Induction and Progression: The Role of Extracellular Matrix and Its Degrading Enzymes M.J. Bissell, P.A. Kenny, and D.C. Radisky How Do Cancer Cells Acquire the Fuel Needed to Support Cell Growth? C.B. Thompson, D.E. Bauer, J.J. Lum, G. Hatzivassiliou, W.-X. Zong, D. Ditsworth, F. Zhao, M. Buzzai, and T. Lindsten Mitochondria and Cancer: Warburg Addressed D.C. Wallace Inductions of Complete Regressions of Oncogene-induced Breast Tumors in Mice R. Benezra, E. Henke, A. Ciarrocchi, M. Ruzinova, D. Solit, N. Rosen, D. Nolan, V. Mittal, and P. de Candia The Fibroblastic Coconspirator in Cancer Progression M. Egeblad, L.E. Littlepage, and Z. Werb Angiogenesis Is Oncogene Addiction Angiogenesis-dependent? J. Folkman and S. Ryeom Structural Basis for the Functions of Endogenous Angiogenesis Inhibitors M.A. Grant and R. Kalluri VEGF Trap as a Novel Antiangiogenic Treatment Currently in Clinical Trials for Cancer and Eye Diseases, and VelociGene-based Discovery of the Next Generation of Angiogenesis Targets J.S. Rudge, G. Thurston, S. Davis, N. Papadopoulos, N. Gale, S.J. Wiegand, and G.D. Yancopoulos Discovering Cancer Targets Molecular Targeted Therapy of Lung Cancer: EGFR Mutations and Response to EGFR Inhibitors D.A. Haber, D.W. Bell, R. Sordella, E.L. Kwak, N. Godin-Heymann, S.V. Sharma, T.J. Lynch, and J. Settleman Aberrant Gene Silencing in Tumor Progression: Implications for Control of Cancer S.B. Baylin and W.Y. Chen Dissecting Cancer Pathways and Vulnerabilities with RNAi T.F. Westbrook, F. Stegmeier, and S.J. Elledge Emerging Approaches in Molecular Profiling Affecting Oncology Drug Discovery S.H. Friend Screens Using RNAi and cDNA Expression as Surrogates for Genetics in Mammalian Tissue Culture Cells J. Pearlberg, S. Degot, W. Endege, J. Park, J. Davies, E. Gelfand, J. Sawyer, A. Conery, J. Doench, W. Li, L. Gonzalez, F.M. Boyce, L. Brizuela, J. LaBaer, D. Grueneberg, and E. Harlow Cancer Targets in the Ras Pathway P. Rodriguez-Viciana, O. Tetsu, K. Oda, J. Okada, K. Rauen, and F. McCormick Author Index Subject Index


Szczegóły: Molecular Approaches to Controlling Cancer - Stillman

Tytuł: Molecular Approaches to Controlling Cancer
Autor: Stillman
Producent: Cold Spring Harbor Laboratory Press
ISBN: 9780879697747
Rok produkcji: 2006
Ilość stron: 538
Oprawa: Miękka
Waga: 1.4 kg


Recenzje: Molecular Approaches to Controlling Cancer - Stillman

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Molecular Approaches to Controlling Cancer

The 2005 Cold Spring Harbor Symposium on Quantitative Biology focused on molecular strategies aimed at understanding and controlling the cancerous state. The resulting volume, with contributions from the world's leading laboratories, covers many aspects of cancer genetics, including DNA repair, telomeres, animal models, stem cells, and therapeutic approaches.Symposium Participants Dedication Foreword Cancer Genetics and Genomes Oncogenes Come of Age H. Varmus, W. Pao, K. Politi, K. Podsypanina, and Y.-C.N. Du Common and Contrasting Genomic Profiles among the Major Human Lung Cancer Subtypes G. Tonon, C. Brennan, A. Protopopov, G. Maulik, B. Feng, Y. Zhang, D.B. Khatry, M.J. You, A.J. Aguirre, E.S. Martin, Z. Yang, H. Ji, L. Chin, K.-K. Wong, and R.A. DePinho Lineage Addiction in Human Cancer: Lessons from Integrated Genomics L.A. Garraway, B.A. Weir, X. Zhao, H. Widlund, R. Beroukhim, A. Berger, D. Rimm, M.A. Rubin, D.E. Fisher, M.L. Meyerson, and W.R. Sellers Polygenic Inherited Predisposition to Breast Cancer B.A.J. Ponder, A. Antoniou, A. Dunning, D.F. Easton, and P.D.P. Pharoah Somatic Mutations in Human Cancer: Insights from Resequencing the Protein Kinase Gene Family P.A. Futreal, R. Wooster, and M.R. Stratton High-Resolution ROMA CGH and FISH Analysis of Aneuploid and Diploid Breast Tumors J. Hicks, L. Muthuswamy, A. Krasnitz, N. Navin, M. Riggs, V. Grubor, D. Esposito, J. Alexander, J. Troge, M. Wigler, S. Maner, P. Lundin, and A. Zetterberg Ductal Pancreatic Cancer in Humans and Mice D.A. Tuveson and S.R. Hingorani Detection of Oncogenic Mutations in the EGFR Gene in Lung Adenocarcinoma with Differential Sensitivity to EGFR Tyrosine Kinase Inhibitors R.K. Thomas, H. Greulich, Y. Yuza, J.C. Lee, T. Tengs, W. Feng, T.-H. Chen, E. Nickerson, J. Simons, M. Egholm, J.M. Rothberg, W.R. Sellers, and M.L. Meyerson Two Decades of Cancer Genetics: From Specificity to Pleiotropic Networks S. Grisendi and P.P. Pandolfi DNA Damage Response Abnormalities of the Inactive X Chromosome Are a Common Feature of BRCA1 Mutant and Sporadic Basal-like Breast Cancer S. Ganesan, A.L. Richardson, Z.C. Wang, J.D. Iglehart, A. Miron, J. Feunteun, D. Silver, and D.M. Livingston The ATM-dependent DNA Damage Signaling Pathway R. Kitagawa and M.B. Kastan Single-Nucleotide Polymorphisms in the p53 Pathway S.L. Harris, G. Gil, W. Hu, H. Robins, E. Bond, K. Hirshfield, Z. Feng, X. Yu, A.K. Teresky, G. Bond, and A.J. Levine Transcriptional Regulation by p53 and p73 M. Lokshin, T. Tanaka, and C. Prives p53-Dependent and -Independent Functions of the Arf Tumor Suppressor C.J. Sherr, D. Bertwistle, W. den Besten, M.-L. Kuo, M. Sugimoto, K. Tago, R.T. Williams, F. Zindy, and M.F. Roussel Exploiting the DNA Repair Defect in BRCA Mutant Cells in the Design of New Therapeutic Strategies for Cancer A.N.J. Tutt, C.J. Lord, N. McCabe, H. Farmer, N. Turner, N.M. Martin, S.P. Jackson, G.C.M. Smith, and A. Ashworth Cancer Biology and Stem Cells Identifying Site-specific Metastasis Genes and Functions G.P. Gupta, A.J. Minn, Y. Kang, P.M. Siegel, I. Serganova, C. Cord f3;n-Cardo, A.B. Olshen, W.L. Gerald, and J. Massagu e9; The von Hippel-Lindau Tumor Suppressor Protein: Roles in Cancer and Oxygen Sensing W.G. Kaelin, Jr. The Src Substrate Tks5, Podosomes (Invadopodia), and Cancer Cell Invasion S.A. Courtneidge, E.F. Azucena, Jr., I. Pass, D.F. Seals, and L. Tesfay Modeling Neurofibromatosis Type 1 Tumors in the Mouse for Therapeutic Intervention L.F. Parada, C.-H. Kwon, and Y. Zhu Stem Cell Self-Renewal and Cancer Cell Proliferation Are Regulated by Common Networks That Balance the Activation of Proto-oncogenes and Tumor Suppressors R. Pardal, A.V. Molofsky, S. He, and S.J. Morrison Prostate Stem Cells and Prostate Cancer D.A. Lawson, L. Xin, R. Lukacs, Q. Xu, D. Cheng, and O.N. Witte Telomeres, Senescence, and Aging Telomere-related Genome Instability in Cancer T. de Lange Telomerase and Cancer Stem Cells M. Armanios and C.W. Greider Regulation of Telomerase by Human Papillomaviruses D.A. Galloway, L.C. Gewin, H. Myers, W. Luo, C. Grandori, R.A. Katzenellenbogen, and J.K. McDougall Animal Models for Cancer Genomic Progression in Mouse Models for Liver Tumors A.D. Tward, K.D. Jones, S. Yant, M.A. Kay, R. Wang, and J.M. Bishop Genotype-Phenotype Relationships in a Mouse Model for Human Small-Cell Lung Cancer J. Calb f3;, R. Meuwissen, E. van Montfort, O. van Tellingen, and A. Berns Cell Cycle and Cancer: Genetic Analysis of the Role of Cyclin-dependent Kinases M. Barbacid, S. Ortega, R. Sotillo, J. Odajima, A. Mart ed;n, D. Santamar ed;a, P. Dubus, and M. Malumbres Mouse Models of Human Non-Small-Cell Lung Cancer: Raising the Bar C.F.B. Kim, E.L. Jackson, D.G. Kirsch, J. Grimm, A.T. Shaw, K. Lane, J. Kissil, K.P. Olive, A. Sweet-Cordero, R. Weissleder, and T. Jacks Generation and Analysis of Genetically Defined Liver Carcinomas Derived from Bipotential Liver Progenitors L. Zender, W. Xue, C. Cord f3;n-Cardo, G.J. Hannon, R. Lucito, S. Powers, P. Flemming, M.S. Spector, and S.W. Lowe Oncogene-dependent Tumor Suppression: Using the Dark Side of the Force for Cancer Therapy G.I. Evan, M. Christophorou, E.A. Lawlor, I. Ringshausen, J. Prescott, T. Dansen, A. Finch, C. Martins, and D. Murphy Chromosomal Translocation Engineering to Recapitulate Primary Events of Human Cancer A. Forster, R. Pannell, L. Drynan, F. Cano, N. Chan, R. Codrington, A. Daser, N. Lobato, M. Metzler, C.-H. Nam, S. Rodriguez, T. Tanaka, and T. Rabbitts Deciphering Cancer Complexities in Genetically Engineered Mice K. Simin, R. Hill, Y. Song, Q. Zhang, R. Bash, R.D. Cardiff, C. Yin, A. Xiao, K. McCarthy, and T. Van Dyke Gene Expression and Cancer The Evolving Portrait of Cancer Metastasis P.B. Gupta, S. Mani, J. Yang, K. Hartwell, and R.A. Weinberg Genomic Binding and Transcriptional Regulation by the Drosophila Myc and Mnt Transcription Factors A. Orian, S.S. Grewal, P.S. Knoepfler, B.A. Edgar, S.M. Parkhurst, and R.N. Eisenman Regulation of the Arf/p53 Tumor Surveillance Network by E2F P.J. Iaquinta, A. Aslanian, and J.A. Lees Genetic and Epigenetic Changes in Mammary Epithelial Cells Identify a Subpopulation of Cells Involved in Early Carcinogenesis H. Berman, J. Zhang, Y.G. Crawford, M.L. Gauthier, C.A. Fordyce, K. McDermott, M. Sigaroudinia, K. Kozakiewicz, and T.D. Tlsty Epigenetic Changes in Cancer and Preneoplasia J.G. Herman A Genetic Approach to Cancer Epigenetics A.P. Feinberg Tumor Responses to Microenvironment Microenvironmental Regulators of Tissue Structure and Function Also Regulate Tumor Induction and Progression: The Role of Extracellular Matrix and Its Degrading Enzymes M.J. Bissell, P.A. Kenny, and D.C. Radisky How Do Cancer Cells Acquire the Fuel Needed to Support Cell Growth? C.B. Thompson, D.E. Bauer, J.J. Lum, G. Hatzivassiliou, W.-X. Zong, D. Ditsworth, F. Zhao, M. Buzzai, and T. Lindsten Mitochondria and Cancer: Warburg Addressed D.C. Wallace Inductions of Complete Regressions of Oncogene-induced Breast Tumors in Mice R. Benezra, E. Henke, A. Ciarrocchi, M. Ruzinova, D. Solit, N. Rosen, D. Nolan, V. Mittal, and P. de Candia The Fibroblastic Coconspirator in Cancer Progression M. Egeblad, L.E. Littlepage, and Z. Werb Angiogenesis Is Oncogene Addiction Angiogenesis-dependent? J. Folkman and S. Ryeom Structural Basis for the Functions of Endogenous Angiogenesis Inhibitors M.A. Grant and R. Kalluri VEGF Trap as a Novel Antiangiogenic Treatment Currently in Clinical Trials for Cancer and Eye Diseases, and VelociGene-based Discovery of the Next Generation of Angiogenesis Targets J.S. Rudge, G. Thurston, S. Davis, N. Papadopoulos, N. Gale, S.J. Wiegand, and G.D. Yancopoulos Discovering Cancer Targets Molecular Targeted Therapy of Lung Cancer: EGFR Mutations and Response to EGFR Inhibitors D.A. Haber, D.W. Bell, R. Sordella, E.L. Kwak, N. Godin-Heymann, S.V. Sharma, T.J. Lynch, and J. Settleman Aberrant Gene Silencing in Tumor Progression: Implications for Control of Cancer S.B. Baylin and W.Y. Chen Dissecting Cancer Pathways and Vulnerabilities with RNAi T.F. Westbrook, F. Stegmeier, and S.J. Elledge Emerging Approaches in Molecular Profiling Affecting Oncology Drug Discovery S.H. Friend Screens Using RNAi and cDNA Expression as Surrogates for Genetics in Mammalian Tissue Culture Cells J. Pearlberg, S. Degot, W. Endege, J. Park, J. Davies, E. Gelfand, J. Sawyer, A. Conery, J. Doench, W. Li, L. Gonzalez, F.M. Boyce, L. Brizuela, J. LaBaer, D. Grueneberg, and E. Harlow Cancer Targets in the Ras Pathway P. Rodriguez-Viciana, O. Tetsu, K. Oda, J. Okada, K. Rauen, and F. McCormick Author Index Subject Index

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