Textbook of Drug Design and Discovery 4e

Textbook of Drug Design and Discovery 4e

  • Producent: CRC Press Inc.
  • Rok produkcji: 2009
  • ISBN: 9781420063226
  • Ilość stron: 476
  • Oprawa: Twarda
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Opis: Textbook of Drug Design and Discovery 4e - U Madsen

The molecular biological revolution and the mapping of the human genome continue to provide new challenges and opportunities for drug research and design. Future medicinal chemists and drug designers must have a firm background in a number of related scientific disciplines in order to understand the conversion of new insight into lead structures and subsequently into drug candidates. Classroom tested and student approved, "Textbook of Drug Design and Discovery, Fourth Edition" describes the manner in which medicinal chemists utilize the various fields upon which they draw and the specific strategies they employ to advance promising molecules into clinical use for the treatment of disease. This text integrates a number of related scientific disciplines, including advanced synthetic chemistry, computational chemistry, biochemistry, structural biology, and molecular pharmacology, to provide current and comprehensive information on all aspects of drug design and discovery. Extensively revised, new topics in the fourth edition include: biostructure-based and ligand-based drug design; chemical biology; natural products; imaging; neurotransmitter transporters; opioid and cannabinoid receptors; hypnotics; neglected diseases; immunomodulating agents; and, antibiotics. The first part of the book covers general aspects, methods, and principles for drug design and discovery, and the second part covers specific targets and diseases. The text contains more than 300 color figures and 24 tables for rapid assimilation. Each chapter includes references for further study. Most chapters also provide the background and history needed to provide a context for students, as well as conclusions that summarize the points most relevant to emerging areas of research in drug design. "... figures are relevant and helpful in explaining concepts in the text. The level of detail in the contents of the book makes it especially suitable for academics and advanced students of medicinal chemistry, but may also be of interest to molecular pharmacologists. biochemists, and others of related disciplines." -ChromatographiaIntroduction to Drug Design and Discovery, P. Krogsgaard-Larsen and L. Bunch Molecular Recognition in Ligand-Protein Binding, T. Liljefors Biostructure-Based Drug Design, F. S. Jorgensen and J. S. Kastrup Ligand-Based Drug Design, I. Pettersson, T. Balle, and T. Liljefors Chemical Biology, K. Stromgaard Stereochemistry in Drug Design, M. B. Mayo-Martin and D. E. Jane Natural Products in Drug Discovery, G. T. Carter Imaging in Drug Discovery and Development, M. Rudin and T. Mueggler Peptides and Peptidomimetics, M. Cai, V. V. Kulkarni, and V. J. Hruby Prodrugs: Design and Development, A. Buur and N. Mork Metals in Medicine: Inorganic Medicinal Chemistry, H. R. Hansen and O. Farver Enzyme Inhibitors: Biostructure-Based and Mechanism-Based Designs, R. A. Copeland, R. R. Gontarek, and L. Luo Receptors: Structure, Function, and Pharmacology, H. Brauner-Osborne Ion Channels: Structure and Function, S.-P. Olesen and D. B. Timmermann Neurotransmitter Transporters: Structure and Function, C. J. Loland and U. Gether GABA and Glutamic Acid Receptor Ligands, B. Frolund and U. Madsen Acetylcholine, A. A. Jensen and P. Krogsgaard-Larsen Histamine Receptors, I. de Esch, H. Timmerman, and R. Leurs Dopamine and Serotonin, B. Bang-Andersen and K. P. Bogeso Opioid and Cannabinoid Receptors, R. P. Clausen and H. S. Hansen Hypnotics, B. Ebert and K. A. Wafford Neglected Diseases, S. B. Christensen Immunomodulating Agents, U. G. Sidelmann Anticancer Agents, F. Bjorkling and L. H. Jensen Antiviral Drugs, E. De Clercq Antibiotics, P. Herdewijn Index


Szczegóły: Textbook of Drug Design and Discovery 4e - U Madsen

Tytuł: Textbook of Drug Design and Discovery 4e
Autor: U Madsen
Producent: CRC Press Inc.
ISBN: 9781420063226
Rok produkcji: 2009
Ilość stron: 476
Oprawa: Twarda
Waga: 1.18 kg


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