Development and Application of Biomarkers

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Opis: Development and Application of Biomarkers - Roger L. Lundblad, R Lundblad

First introduced to biomedical research in 1980, the term biomarker has taken on a life of its own in recent years and has come to mean a number of things. In biomedical science, biomarker has evolved to most commonly mean a characteristic that can be used either as a diagnostic or a prognostic, but most significantly as a screening indicator for pathologies that tend to be somewhat silent prior to overt clinical display. Applying scientific rigor, as well as a disciplined approach to nomenclature, Roger Lundblad's Development and Application of Biomarkers rationalizes the current enthusiasm for biomarkers with the use of well-established clinical laboratory analytes in clinical medicine. Highly respected for his work as both a classical protein scientist and as a pioneer in proteomics, Dr. Lundblad catalogs various biomarkers recognized in clinical medicine and, where possible, matches the expectations for advances in screening technologies with the realities of statistical analysis. More specifically, this important reference: Details an extensive list of biomarkers for various stages of a number of cancer types including ovarian, pancreatic, prostate, and breast cancer Looks at how proteomics is used for the discovery and validation of biomarkers Explores the use of microarray technology, ultra-high performance liquid chromatography, and computational bioinformatic approaches for the discovery and use of biomarkers Examines the use of cells and cell fragments as more complex biomarkers Organizes a host of significant biomarkers and essential research by type and use in a series of readily accessible tables Throughout this volume, Dr. Lundblad encourages consideration of biomarkers more as a concept than as laboratory analytes, emphasizing the relation between the discovery of a biomarker and the biology underlying its production. Ultimately, it is a thorough understanding of that underlying biology that will lead to the development of assays that are robust and reproducible, as well as clinically significant.Introduction to Biomarkers Application of Biomarkers in Diagnostics, Prognostics, Theranostics, and Personalized Medicine Introduction Nomenclature/Definitions Biomarkers and Diagnostics Biomarkers and Screening Biomarkers and Prognosis Biomarkers and Theranostics and Personalized Medicine Biomarkers and Specific Pathologies Rheumatoid Arthritis Inflammation Biomarkers in Different Pathologies Biomarkers in Ophthalmology Biomarkers in Neurology Cardiac Biomarkers Biomarkers in Renal Disease Biomarkers for Bone Biomarkers for Exposure to Environmental Toxins Biomarkers and the Development of Biopharmaceuticals Development of Biomarkers for Oncology Intermediate Biomarkers and the Precancerous Condition Cancer and Inflammation Head and Neck Cancer Ovarian Cancer Pancreatic Cancer Prostate Cancer Breast Cancer The Use of Proteomics to Discover Biomarkers Blood Urine Saliva Miscellaneous Biological Fluids/Excretory Products as Sources of Biomarkers Biomarkers in Tissue Samples Modified Proteins, Oligosaccharides, and Oligonucleotidesas Biomarkers Complex Biomarkers: Cells, Cell Membrane Proteins, and Cell Fragments as Biomarkers Use of Microarray Technology in Biomarker Discovery and Development Development of Assays for Biomarkers Appendix A: Model Standard Operating Procedure for an Assay references provided at the end of every chapter


Szczegóły: Development and Application of Biomarkers - Roger L. Lundblad, R Lundblad

Tytuł: Development and Application of Biomarkers
Autor: Roger L. Lundblad, R Lundblad
Producent: CRC Press Inc.
ISBN: 9781439819791
Rok produkcji: 2010
Ilość stron: 297
Oprawa: Twarda
Waga: 0.55 kg


Recenzje: Development and Application of Biomarkers - Roger L. Lundblad, R Lundblad

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Development and Application of Biomarkers

,

First introduced to biomedical research in 1980, the term biomarker has taken on a life of its own in recent years and has come to mean a number of things. In biomedical science, biomarker has evolved to most commonly mean a characteristic that can be used either as a diagnostic or a prognostic, but most significantly as a screening indicator for pathologies that tend to be somewhat silent prior to overt clinical display. Applying scientific rigor, as well as a disciplined approach to nomenclature, Roger Lundblad's Development and Application of Biomarkers rationalizes the current enthusiasm for biomarkers with the use of well-established clinical laboratory analytes in clinical medicine. Highly respected for his work as both a classical protein scientist and as a pioneer in proteomics, Dr. Lundblad catalogs various biomarkers recognized in clinical medicine and, where possible, matches the expectations for advances in screening technologies with the realities of statistical analysis. More specifically, this important reference: Details an extensive list of biomarkers for various stages of a number of cancer types including ovarian, pancreatic, prostate, and breast cancer Looks at how proteomics is used for the discovery and validation of biomarkers Explores the use of microarray technology, ultra-high performance liquid chromatography, and computational bioinformatic approaches for the discovery and use of biomarkers Examines the use of cells and cell fragments as more complex biomarkers Organizes a host of significant biomarkers and essential research by type and use in a series of readily accessible tables Throughout this volume, Dr. Lundblad encourages consideration of biomarkers more as a concept than as laboratory analytes, emphasizing the relation between the discovery of a biomarker and the biology underlying its production. Ultimately, it is a thorough understanding of that underlying biology that will lead to the development of assays that are robust and reproducible, as well as clinically significant.Introduction to Biomarkers Application of Biomarkers in Diagnostics, Prognostics, Theranostics, and Personalized Medicine Introduction Nomenclature/Definitions Biomarkers and Diagnostics Biomarkers and Screening Biomarkers and Prognosis Biomarkers and Theranostics and Personalized Medicine Biomarkers and Specific Pathologies Rheumatoid Arthritis Inflammation Biomarkers in Different Pathologies Biomarkers in Ophthalmology Biomarkers in Neurology Cardiac Biomarkers Biomarkers in Renal Disease Biomarkers for Bone Biomarkers for Exposure to Environmental Toxins Biomarkers and the Development of Biopharmaceuticals Development of Biomarkers for Oncology Intermediate Biomarkers and the Precancerous Condition Cancer and Inflammation Head and Neck Cancer Ovarian Cancer Pancreatic Cancer Prostate Cancer Breast Cancer The Use of Proteomics to Discover Biomarkers Blood Urine Saliva Miscellaneous Biological Fluids/Excretory Products as Sources of Biomarkers Biomarkers in Tissue Samples Modified Proteins, Oligosaccharides, and Oligonucleotidesas Biomarkers Complex Biomarkers: Cells, Cell Membrane Proteins, and Cell Fragments as Biomarkers Use of Microarray Technology in Biomarker Discovery and Development Development of Assays for Biomarkers Appendix A: Model Standard Operating Procedure for an Assay references provided at the end of every chapter

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Cena 631,05 PLN
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Oszczędzasz 6%
Wysyłka: Niedostępna
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Szczegóły: Development and Application of Biomarkers - Roger L. Lundblad, R Lundblad

Tytuł: Development and Application of Biomarkers
Autor: Roger L. Lundblad, R Lundblad
Producent: CRC Press Inc.
ISBN: 9781439819791
Rok produkcji: 2010
Ilość stron: 297
Oprawa: Twarda
Waga: 0.55 kg


Recenzje: Development and Application of Biomarkers - Roger L. Lundblad, R Lundblad

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