Toxicologic Pathology

Toxicologic Pathology

  • Producent: CRC Press Inc.
  • Rok produkcji: 2013
  • ISBN: 9781439872109
  • Ilość stron: 1015
  • Oprawa: Twarda
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Cena 916,00 PLN
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Opis: Toxicologic Pathology

As drug development shifts over time to address unmet medical needs and more targeted therapies are developed, previously unseen pharmacological or off-target effects may occur in treatment. Designed to provide practical information for the bench toxicologic pathologist working in pharmaceutical drug research, Toxicologic Pathology: Nonclinical Safety Assessment presents a histopathologic description of lesions observed during drug development and discusses their implication in the drug development process. Divided into two sections, the book systematically assists pathologists in making a determination as to the origin and potential importance of a lesion and its relevance for assessing human risk. The first section includes eight "concept" chapters to orient pathologists in areas that are important for effective interaction with other pathologists as well as the many non-pathologists involved in drug development. The second section is made up of organ-based chapters, each including light microscopic and electron microscopic descriptions of pathological lesions, differential diagnoses, biological consequences, pathogenesis, mechanism of lesion formation, and the expected clinical pathology correlates. This volume presents critical information-both published and unpublished and gained through personal experience-to improve the quality of drug safety evaluation and to expedite and improve the efficiency of the process. This book is crafted to assist students, residents, and toxicologic pathologists in their early career phase by serving as a resource that can effectively be used as a ready reference next to the microscope. In addition, more experienced pathologists will find this volume to be invaluable during their assessments. The book is also a valuable reference for toxicologists to assist in understanding compound-related pathological findings and to provide background for working on a range of toxicological problems.Concepts in Drug Development Overview of Drug Development James A. Popp and Jeffery A. Engelhardt Nonclinical Safety Evaluation of Drugs Thomas M. Monticello and Jeanine L. Bussiere Toxicokinetics and Drug Disposition David D. Christ Introduction to Toxicologic Pathology Judit E. Markovits, Page R. Bouchard, Christopher J. Clarke, and Donald N. McMartin Routine and Special Techniques in Toxicologic Pathology Daniel J. Patrick and Peter C. Mann Principles of Clinical Pathology Robert L. Hall Toxicogenomics in Toxicologic Pathology Mark J. Hoenerhoff and David E. Malarkey Spontaneous Lesions in Control Animals Used in Toxicity Studies Robert C. Johnson, Robert H. Spaet, and Daniel L. Potenta Organ Systems Gastrointestinal Tract Judit E. Markovits, Graham R. Betton, Donald N. McMartin, and Oliver C. Turner Liver, Gallbladder, and Exocrine Pancreas Russell C. Cattley, James A. Popp, and Steven L. Vonderfecht Respiratory System David J. Lewis and Tom P. McKevitt Urinary System Kendall S. Frazier and John Curtis Seely Hematopoietic System Kristin Henson, Glenn Elliott, and Gregory S. Travlos Lymphoid System Patrick J. Haley Bone, Muscle, and Tooth John L. Vahle, Joel R. Leininger, Philip H. Long, D. Greg Hall, and Heinrich Ernst Cardiovascular System Calvert Louden and David Brott Endocrine Glands Sundeep Chandra, Mark J. Hoenerhoff, and Richard Peterson Reproductive System and Mammary Gland Justin D. Vidal, Michael L. Mirsky, Karyn Colman, Katharine M. Whitney, and Dianne M. Creasy Skin Zbigniew W. Wojcinski, Lydia Andrews-Jones, Daher Ibrahim Aibo, and Robert Dunstan Nervous System Mark T. Butt, Robert Sills, and Alys Bradley Special Senses: Eye and Ear James A. Render, Kenneth A. Schafer, and Richard A. Altschuler


Szczegóły: Toxicologic Pathology

Tytuł: Toxicologic Pathology
Producent: CRC Press Inc.
ISBN: 9781439872109
Rok produkcji: 2013
Ilość stron: 1015
Oprawa: Twarda
Waga: 2.28 kg


Recenzje: Toxicologic Pathology

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