Opis: Vitamin-Binding Proteins
Diverse in chemical nature, water soluble and lipid soluble vitamins are essential micronutrients that react with specific protein entities and are transported to sites for participation in intracellular events, both at the genomic and non-genomic levels. Thus, metabolic pathways and intracellular signaling are influenced by vitamins or their derivatives through vitamin binding to specific proteins. Vitamin-Binding Proteins: Functional Consequences examines the function of various vitamins based on this binding, as well as their role as antioxidants, leading to effects on intracellular mechanisms. This book explores the resulting functional consequences at the level of cells, tissues, and organs as well as the neurological, endocrine, and immune systems. The text addresses the effects that lead to both normal physiological function and pharmacological activity with significant therapeutic potential in a wide spectrum of disease processes. Leading experts discuss various vitamins including the function of retinoids in development, immunity, and obesity; the role of vitamin D in the immune system, infectious processes, and cardiovascular disease; and the effects of vitamins E, C, and K on the vascular system. Chapters cover the therapeutic potential of the vitamin B6 vitamer pyridoxamine and the lipid-soluble B1analogue benfotiamine. They also describe various functions of biotin as well as gene transcriptional regulation through biotin and biotin-binding proteins. The text addresses folate receptor-mediated therapeutics, vitamin B12 derivatives in tumor targeting, and implication of ascorbic acid in different disorders. Expounding newer areas of vitamin function, this book explores the interface of physiological vitamin function and pharmacological vitamin action, offering a broad perspective of possible vitamin binding therapeutics.Retinoic Acid: Metabolism, Developmental Functions, and Evolution Joao E. Carvalho and Michael Schubert Serum Retinol-Binding Protein, Obesity, and Insulin Resistance Pangala V. Bhat and Daniel-Constantin Manolescu Retinoic Acid and Immunity Yoshishige Miyabe, Chie Miyabe, and Toshihiro Nanki Vitamin D3 Up-Regulated Protein 1 (VDUP1) and the Immune System Hyun Woo Suh, Hye Young Jung, Young Jun Park, and Inpyo Choi Rapid Pre-Genomic Responses of Vitamin D Tremaine M. Sterling, Ramesh C. Khanal, Yu Meng, Yang Zhang, and Ilka Nemere The Role of Vitamin D in Infectious Processes Russell W. Chesney Vitamin D, Vitamin D Binding Protein, and Cardiovascular Disease Diane Berry and Elina Hypponen Vitamins E and C: Effects on Matrix Components in the Vascular System Jean-Marc Zingg, Mohsen Meydani, and Angelo Azzi Vitamin K and Vascular Calcification Chandrasekar Palaniswamy, Wilbert S. Aronow, Jagadish Khanagavi, and Arunabh Sekhri Therapeutic Effects of Pyridoxamine and Benfotiamine Shyamala Dakshinamurti and Krishnamurti Dakshinamurti Multifaceted Therapeutic Potential of Vitamin B6 Shyamala Dakshinamurti and Krishnamurti Dakshinamurti Non-Prosthetic Group Functions of Biotin Krishnamurti Dakshinamurti Mechanisms of Gene Transcriptional Regulation Through Biotin and Biotin-Binding Proteins in Mammals Janos Zempleni, Dandan Liu, Daniel Camara Teixeira, and Mahendra P. Singh Folate Receptor-Mediated Therapeutics: Folate Receptor- Mediated Particle Systems for Drug and Gene Delivery in Cancer Therapy Yoshie Maitani Vitamin B12 Derivatives and Preferential Targeting of Tumors Evelyne Furger and Eliane Fischer Ascorbic Acid, Binding Proteins, and Pathophysiology F. Rahman and Michael Fontes
Szczegóły: Vitamin-Binding Proteins
Tytuł: Vitamin-Binding Proteins
Producent: CRC Press Inc.
Rok produkcji: 2013
Ilość stron: 300
Waga: 0.57 kg