Wnt Signaling in Development and Disease

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Opis: Wnt Signaling in Development and Disease - Randall T. Moon, Stefan Hoppler

Widely recognized as one of the most important signaling mechanisms in development and disease, Wnt signaling pathways are networks of proteins that play significant roles in embryogenesis or cancer development. Wnt Signaling in Development and Disease addresses the fundamentals of Wnt signaling and delves into molecular pathway mechanisms, its role in embryogenesis, adult tissue homeostasis, and chronic disease. This comprehensive resource details current knowledge of Wnt signaling while looking ahead to future progress.Contributors vii Preface xi Part 1 Molecular Signaling Mechanisms: From Pathways to Networks 1 1 Wnt Signal Production, Secretion, and Diffusion 3 Madelon M. Maurice and Hendrik C. Korswagen 2 Wnt Signaling at the Membrane 15 Gary Davidson and Christof Niehrs 3 Wnt Signal Transduction in the Cytoplasm: an Introduction to the Destruction Complex 33 Tony W. Chen, Heather A. Wallace, Yashi Ahmed, and Ethan Lee 4 An Overview of Gene Regulation by Wnt/beta-Catenin Signaling 51 Chen U. Zhang and Ken M. Cadigan 5 Finding a Needle in a Genomic Haystack: Genome-Wide Approaches to Identify Wnt/TCF Transcriptional Targets 73 Chandan Bhambhani and Ken M. Cadigan 6 Introduction to beta-Catenin-Independent Wnt Signaling Pathways 89 Susanne Kuhl and Michael Kuhl 7 Molecular Mechanisms of Wnt Pathway Specificity 101 Alexandra Schambony, Guido J.R. Zaman, and Folkert Verkaar 8 Modulation of Wnt Signaling by Endocytosis of Receptor Complexes 113 Akira Kikuchi, Shinji Matsumoto, Katsumi Fumoto, and Akira Sato 9 New Insights from Proteomic Analysis of Wnt Signaling 125 Matthew P. Walker, Dennis Goldfarb, and Michael B. Major 10 New Insights about Wnt/beta-Catenin Pathway Mechanisms from Global siRNA Screens 137 Tenzin Gocha and Ramanuj DasGupta 11 Mathematical Models of Wnt Signaling Pathways 153 Michael Kuhl, Barbara Kracher, Alexander Gross, and Hans A. Kestler 12 The Wnt's Tale: On the Evolution of a Signaling Pathway 161 Jenifer C. Croce and Thomas W. Holstein Part 2 Selected Key Molecules in Wnt Signaling 177 13 Secreted Wnt Inhibitors or Modulators 179 Paola Bovolenta, Anne-Kathrin Gorny, Pilar Esteve, and Herbert Steinbeisser 14 Frizzleds as G Protein-Coupled Receptors 195 Gunnar Schulte 15 Dishevelled at the Crossroads of Pathways 207 Vitizslav Bryja and Ondoej Bernatik 16 beta-Catenin: a Key Player in Both Cell Adhesion and Wnt Signaling 217 Jonathan Pettitt 17 Evolutionary Diversification of Vertebrate TCF/LEF Structure, Function, and Regulation 225 Stefan Hoppler and Marian L. Waterman 18 Insights from Structural Analysis of Protein--Protein Interactions by Wnt Pathway Components and Functional Multiprotein Complex Formation 239 Zhihong Cheng and Wenqing Xu Part 3 Wnt Signaling in Embryonic Development and Adult Tissue Homeostasis 251 19 Wnt Signaling in Early Vertebrate Development: From Fertilization to Gastrulation 253 Eliza Zylkiewicz, Sergei Y. Sokol, and Stefan Hoppler 20 Wnt/beta-Catenin Signaling in Embryonic Stem Cells: Insights into Early Mammalian Development 267 Kathryn C. Davidson 21 Wnt Signaling in Neural Development 279 Richard I. Dorsky 22 Wnt Signaling in Heart Organogenesis 293 Stefan Hoppler, Silvia Mazzotta, and Michael Kuhl 23 Wnt Signaling in Kidney Organogenesis 303 Kimmo Halt and Seppo Vainio 24 Wnt Signaling Regulation of Tissue Architecture (EMT and MET) and Morphogenesis: Consequences for Colorectal and Liver Cancer 315 Theodora Fifis, Bang M. Tran, Renate H.M. Schwab, Timothy M. Johanson, Nadia Warner, Nick Barker, and Elizabeth Vincan 25 Wnt Signaling in Adult Stem Cells: Tissue Homeostasis and Regeneration 329 Frank J.T. Staal and Riccardo Fodde 26 Restoring Tissue Homeostasis: Wnt Signaling in Tissue Regeneration After Acute Injury 339 Gunes Ozhan and Gilbert Weidinger Part 4 Wnt Signaling in Chronic Disease 357 27 Wnt Signaling and Colorectal Cancer 359 Kevin Myant and Owen J. Sansom 28 Wnt Signaling in Melanoma 369 Jamie N. Anastas and Andy J. Chien 29 Wnt Signaling in Mood and Psychotic Disorders 379 Stephen J. Haggarty, Karun Singh, Roy H. Perlis, and Rakesh Karmacharya 30 Neuropsychiatric Disease-Associated Genetic Variation in the Wnt Pathway 393 Stephen J. Haggarty, Karun Singh, Roy H. Perlis, and Rakesh Karmacharya 31 Wnt Signaling in Dementia 411 Stephen J. Haggarty 32 Therapeutic Targeting of the Wnt Signaling Network 421 Felicity Rudge and Trevor Dale Index 445


Szczegóły: Wnt Signaling in Development and Disease - Randall T. Moon, Stefan Hoppler

Tytuł: Wnt Signaling in Development and Disease
Autor: Randall T. Moon, Stefan Hoppler
Producent: John Wiley
ISBN: 9781118444160
Rok produkcji: 2014
Ilość stron: 472
Oprawa: Twarda
Waga: 1.11 kg


Recenzje: Wnt Signaling in Development and Disease - Randall T. Moon, Stefan Hoppler

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Przypomnij hasło
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Wnt Signaling in Development and Disease

,

Widely recognized as one of the most important signaling mechanisms in development and disease, Wnt signaling pathways are networks of proteins that play significant roles in embryogenesis or cancer development. Wnt Signaling in Development and Disease addresses the fundamentals of Wnt signaling and delves into molecular pathway mechanisms, its role in embryogenesis, adult tissue homeostasis, and chronic disease. This comprehensive resource details current knowledge of Wnt signaling while looking ahead to future progress.Contributors vii Preface xi Part 1 Molecular Signaling Mechanisms: From Pathways to Networks 1 1 Wnt Signal Production, Secretion, and Diffusion 3 Madelon M. Maurice and Hendrik C. Korswagen 2 Wnt Signaling at the Membrane 15 Gary Davidson and Christof Niehrs 3 Wnt Signal Transduction in the Cytoplasm: an Introduction to the Destruction Complex 33 Tony W. Chen, Heather A. Wallace, Yashi Ahmed, and Ethan Lee 4 An Overview of Gene Regulation by Wnt/beta-Catenin Signaling 51 Chen U. Zhang and Ken M. Cadigan 5 Finding a Needle in a Genomic Haystack: Genome-Wide Approaches to Identify Wnt/TCF Transcriptional Targets 73 Chandan Bhambhani and Ken M. Cadigan 6 Introduction to beta-Catenin-Independent Wnt Signaling Pathways 89 Susanne Kuhl and Michael Kuhl 7 Molecular Mechanisms of Wnt Pathway Specificity 101 Alexandra Schambony, Guido J.R. Zaman, and Folkert Verkaar 8 Modulation of Wnt Signaling by Endocytosis of Receptor Complexes 113 Akira Kikuchi, Shinji Matsumoto, Katsumi Fumoto, and Akira Sato 9 New Insights from Proteomic Analysis of Wnt Signaling 125 Matthew P. Walker, Dennis Goldfarb, and Michael B. Major 10 New Insights about Wnt/beta-Catenin Pathway Mechanisms from Global siRNA Screens 137 Tenzin Gocha and Ramanuj DasGupta 11 Mathematical Models of Wnt Signaling Pathways 153 Michael Kuhl, Barbara Kracher, Alexander Gross, and Hans A. Kestler 12 The Wnt's Tale: On the Evolution of a Signaling Pathway 161 Jenifer C. Croce and Thomas W. Holstein Part 2 Selected Key Molecules in Wnt Signaling 177 13 Secreted Wnt Inhibitors or Modulators 179 Paola Bovolenta, Anne-Kathrin Gorny, Pilar Esteve, and Herbert Steinbeisser 14 Frizzleds as G Protein-Coupled Receptors 195 Gunnar Schulte 15 Dishevelled at the Crossroads of Pathways 207 Vitizslav Bryja and Ondoej Bernatik 16 beta-Catenin: a Key Player in Both Cell Adhesion and Wnt Signaling 217 Jonathan Pettitt 17 Evolutionary Diversification of Vertebrate TCF/LEF Structure, Function, and Regulation 225 Stefan Hoppler and Marian L. Waterman 18 Insights from Structural Analysis of Protein--Protein Interactions by Wnt Pathway Components and Functional Multiprotein Complex Formation 239 Zhihong Cheng and Wenqing Xu Part 3 Wnt Signaling in Embryonic Development and Adult Tissue Homeostasis 251 19 Wnt Signaling in Early Vertebrate Development: From Fertilization to Gastrulation 253 Eliza Zylkiewicz, Sergei Y. Sokol, and Stefan Hoppler 20 Wnt/beta-Catenin Signaling in Embryonic Stem Cells: Insights into Early Mammalian Development 267 Kathryn C. Davidson 21 Wnt Signaling in Neural Development 279 Richard I. Dorsky 22 Wnt Signaling in Heart Organogenesis 293 Stefan Hoppler, Silvia Mazzotta, and Michael Kuhl 23 Wnt Signaling in Kidney Organogenesis 303 Kimmo Halt and Seppo Vainio 24 Wnt Signaling Regulation of Tissue Architecture (EMT and MET) and Morphogenesis: Consequences for Colorectal and Liver Cancer 315 Theodora Fifis, Bang M. Tran, Renate H.M. Schwab, Timothy M. Johanson, Nadia Warner, Nick Barker, and Elizabeth Vincan 25 Wnt Signaling in Adult Stem Cells: Tissue Homeostasis and Regeneration 329 Frank J.T. Staal and Riccardo Fodde 26 Restoring Tissue Homeostasis: Wnt Signaling in Tissue Regeneration After Acute Injury 339 Gunes Ozhan and Gilbert Weidinger Part 4 Wnt Signaling in Chronic Disease 357 27 Wnt Signaling and Colorectal Cancer 359 Kevin Myant and Owen J. Sansom 28 Wnt Signaling in Melanoma 369 Jamie N. Anastas and Andy J. Chien 29 Wnt Signaling in Mood and Psychotic Disorders 379 Stephen J. Haggarty, Karun Singh, Roy H. Perlis, and Rakesh Karmacharya 30 Neuropsychiatric Disease-Associated Genetic Variation in the Wnt Pathway 393 Stephen J. Haggarty, Karun Singh, Roy H. Perlis, and Rakesh Karmacharya 31 Wnt Signaling in Dementia 411 Stephen J. Haggarty 32 Therapeutic Targeting of the Wnt Signaling Network 421 Felicity Rudge and Trevor Dale Index 445

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Cena 634,00 PLN
Nasza cena 592,79 PLN
Oszczędzasz 6%
Wysyłka: Niedostępna
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Szczegóły: Wnt Signaling in Development and Disease - Randall T. Moon, Stefan Hoppler

Tytuł: Wnt Signaling in Development and Disease
Autor: Randall T. Moon, Stefan Hoppler
Producent: John Wiley
ISBN: 9781118444160
Rok produkcji: 2014
Ilość stron: 472
Oprawa: Twarda
Waga: 1.11 kg


Recenzje: Wnt Signaling in Development and Disease - Randall T. Moon, Stefan Hoppler

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