Genetic Variance Detection
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Opis: Genetic Variance Detection - Karl H. Hecker, Hecker

This comprehensive reference for novice students and experienced scientists studying DNA in organisms compares and evaluates the technological choices available in detecting genetic variances in pharmacogenomics. Commonly used technologies such as sequencing, DNA array and chip technologies, mass spectrometry, gel- and chromatography-based technologies, as well as less commonly used methods are described in detail and illustrated with specific examples. Expert advice is presented on technological options to facilitate decisions about the utility and applicability of individual technologies for specific needs. Genetic Variance Detection - Technologies for Pharmacogenomics is Karl Hecker's second book about technologies for genetic variance detection. It broadly covers a wide range of technologies currently used for genetic variance detection and constitutes an essential contribution to the field. A reference guide for every molecular biology laboratory. His first book Genetic Variance Detection - Nuts & Bolts of DHPLC in Genomics (ISBN 0966402774) provides comprehensive and in depth coverage of denaturing high-performance liquid chromatography and is an invaluable reference for anyone using or planning to use DHPLC for genetic variance detection. -- Norbert Arnold, Professor Dr. rer. nat.Chapter 1 Basics of automated, high-accuracy mutation screening with the WAVE[registered] Nucleic Acid Fragment Analysis Systems; Chapter 2 Influence of PCR on DHPLC Polymorphism Characterization; Chapter 3 Denaturing High Performance Liquid Chromatography (DHPLC), an important mutation detection technique in mutation analysis of the breast and ovarian cancer predisposing genes BRCA1 and BRCA2; Chapter 4 Mutation detection in the tuberous sclerosis genes TSC1 and TSC2 by DHPLC; Chapter 5 Rapid analysis to detect base changes in human mitochondrialDNA by restriction enzyme analysis followed by denaturing high performance liquid chromatography; Chapter 6 Mutation analysis of LDLR mutations in patients with familial hypercholesterolaemia; Chapter 7 Novel DHPLC based strategy for identification and characterization of (bi)-clonal T-cell receptor targets for the detection of minimal residual disease in childhood acute lymphoblastic leukemia; Chapter 8 SIRPH: a rapid, quantitative SNuPE-IP RP HPLC method for simultaneous methylation analysis at multiple CpG sites; Chapter 9 Isolation and sequencing of heteroduplex fragments from DHPLC analysis of somatic, low-f requency mutations; Chapter 10 Analysis of promoter methylation using denaturing high-performance liquid chromatography (DHPLC)


Szczegóły: Genetic Variance Detection - Karl H. Hecker, Hecker

Tytuł: Genetic Variance Detection
Autor: Karl H. Hecker, Hecker
Producent: DNA Press
ISBN: 9780966402773
Rok produkcji: 2003
Ilość stron: 190
Oprawa: Miękka
Waga: 0.28 kg


Recenzje: Genetic Variance Detection - Karl H. Hecker, Hecker
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Genetic Variance Detection

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This comprehensive reference for novice students and experienced scientists studying DNA in organisms compares and evaluates the technological choices available in detecting genetic variances in pharmacogenomics. Commonly used technologies such as sequencing, DNA array and chip technologies, mass spectrometry, gel- and chromatography-based technologies, as well as less commonly used methods are described in detail and illustrated with specific examples. Expert advice is presented on technological options to facilitate decisions about the utility and applicability of individual technologies for specific needs. Genetic Variance Detection - Technologies for Pharmacogenomics is Karl Hecker's second book about technologies for genetic variance detection. It broadly covers a wide range of technologies currently used for genetic variance detection and constitutes an essential contribution to the field. A reference guide for every molecular biology laboratory. His first book Genetic Variance Detection - Nuts & Bolts of DHPLC in Genomics (ISBN 0966402774) provides comprehensive and in depth coverage of denaturing high-performance liquid chromatography and is an invaluable reference for anyone using or planning to use DHPLC for genetic variance detection. -- Norbert Arnold, Professor Dr. rer. nat.Chapter 1 Basics of automated, high-accuracy mutation screening with the WAVE[registered] Nucleic Acid Fragment Analysis Systems; Chapter 2 Influence of PCR on DHPLC Polymorphism Characterization; Chapter 3 Denaturing High Performance Liquid Chromatography (DHPLC), an important mutation detection technique in mutation analysis of the breast and ovarian cancer predisposing genes BRCA1 and BRCA2; Chapter 4 Mutation detection in the tuberous sclerosis genes TSC1 and TSC2 by DHPLC; Chapter 5 Rapid analysis to detect base changes in human mitochondrialDNA by restriction enzyme analysis followed by denaturing high performance liquid chromatography; Chapter 6 Mutation analysis of LDLR mutations in patients with familial hypercholesterolaemia; Chapter 7 Novel DHPLC based strategy for identification and characterization of (bi)-clonal T-cell receptor targets for the detection of minimal residual disease in childhood acute lymphoblastic leukemia; Chapter 8 SIRPH: a rapid, quantitative SNuPE-IP RP HPLC method for simultaneous methylation analysis at multiple CpG sites; Chapter 9 Isolation and sequencing of heteroduplex fragments from DHPLC analysis of somatic, low-f requency mutations; Chapter 10 Analysis of promoter methylation using denaturing high-performance liquid chromatography (DHPLC)

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Cena 110,00 PLN
Nasza cena 107,53 PLN
Oszczędzasz 2%
Wysyłka: Niedostępna
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Szczegóły: Genetic Variance Detection - Karl H. Hecker, Hecker

Tytuł: Genetic Variance Detection
Autor: Karl H. Hecker, Hecker
Producent: DNA Press
ISBN: 9780966402773
Rok produkcji: 2003
Ilość stron: 190
Oprawa: Miękka
Waga: 0.28 kg


Recenzje: Genetic Variance Detection - Karl H. Hecker, Hecker

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