N-Heterocyclic Carbenes

  • Producent: VCH
  • Oprawa: Twarda
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Opis: N-Heterocyclic Carbenes

This comprehensive reference and handbook covers in depth all major aspects of the use of N-heterocyclic carbene-complexes in organic synthesis: from the theoretical background to characterization, and from cross-coupling reactions to olefin metathesis.§Edited by a leader and experienced scientist in the field of homogeneous catalysis and use of NHCs, this is an essential tool for every academic and industrial synthetic chemist.LIST OF CONTRIBUTORS§PREFACE§§N-HETEROCYCLIC CERBENES§Introduction§Structure and Properties of NHCs§Abnormal Carbenes§Why Are NHCs Stable?§Bonding of NHCs to Metal Centers§Quantifying the Properties of NHCs§Steric Impact§Electronic Properties§N-Heterocyclic Carbenes in the Context of Other Stable Carbenes§Synthesis of NHCs§Salts and Adducts of NHCs§Summary§References§§TUNING AND QUANTIFYING STERIC AND ELECTRONIC EFFECTS OF N-HETEROCYCLIC CARBENES§Introduction§Steric Effects in NHC ligands§Electronic Effects in NHC Ligands§Conclusions§References§§CHIRAL MONODENDATE N-HETEROCYCLIC CARBENE LIGANDS IN ASYMMETRIC CATALYSIS§Introduction§NHC?Ru§Asymmetric Metathesis§Asymmetric Hydrogenation§Asymmetric Hydrosilylation§NHC?Rh§Asymmetric Catalysis Using Boronic Acids as Nucleophiles§Asymmetric Hydrosilylation§Asymmetric Hydroformylation§NHC?Ir§NHC?Ni§NHC?Pd§Asymmetric Intramolecular a-Arylation of Amides§Asymmetric Diamination§Other Asymmetric Catalysis Using NHC?Pd§NHC?Cu§Asymmetric Conjugate Addition§Asymmetric Allylic Substitution§Silyl Conjugate Addition§Enantioselective ß-Boration§Asymmetric Hydrosilylation§Asymmetric Addition to Imines§NHC?Ag§NHC?Au§Enantioselective Cycloisomerizations§Enantioselective Hydrogenation§Enantioselective Cycloaddition§Conclusion§References§§(N-HETEROCYCLIC CARBENE)?PALLADIUM COMPLEXES IN CATALYSIS§Introduction§Cross-Coupling Reactions§Suzuki?Miyaura Coupling§Buchwald?Hartwig Aminations§Negishi Reactions§Hiyama Coupling§Kumada Coupling§Sonogashira Coupling§Heck Reaction§Chelates and Pincer Ligands§Asymmetric Catalysis§Oxidation Reactions§Telomerization, Oligomerization and Polymerization§Anticancer NHC?Pd Complexes§References§§NHC PLATINUM(0) COMPLEXES: UNIQUE CATALYSTS FOR THE HYDROSILYLATION OF ALKENES AND ALKYNES§Introduction§Hydrosilylation of Alkenes: The Beginning§Initial Results with Phosphine Ligands§NHC Platinum(0) Complexes: The Breakthrough§Synthesis of NHC Platinum(0) Complexes and Kinetic Assays§Functional Group Tolerance and Substrate Scope§Mechanistic Studies§Activation Period§Catalyst Deactivation Pathways§Semiquantitative Kinetic Studies§Quantitative Kinetic Modeling§Conclusions§Hydrosilylation of Alkynes§Catalyst Screening and the Impact of NHCs on Regioselectivity§Influence of Silane on Regioselectivity§Second-Generation Catalyst for the Hydrosilylation of Alkynes§Functional Group Tolerance and Substrate Scope§Mechanistic Studies§Qualitative Kinetic Studies§Catalyst Activation and Deactivation Pathways§Proposed Mechanism§Conclusions§References§§SYNTHESIS AND MEDICINAL PROPERTIES OF SILVER?NHC COMPLEXES AND IMIDAZOLIUM SALTS§Introduction§Silver?NHC Complexes as Antimicrobial Agents§Silver?NHC Complexes as Anticancer Agents§Conclusions§References§§MEDICAL APPLICATIONS OF NHC?GOLD AND ?COPPER COMPLEXES§Introduction§Gold Antimicrobial Agents§Metals as Antitumor Reagents§Copper Complexes as Antitumoral Reagents§Conclusion§References§§NHC?COPPER COMPLEXES AND THEIR APPLICATIONS§Introduction§History of NHC?Copper Systems§Hydrosilylation§Allene Formation§1,4-Reduction§Conjugate Addition§Zinc Reagents§Grignard Reagents§Aluminum Reagents§Boron Reagents§Hydrothiolation, Hydroalkoxylation, Hydroamination§Carboxylation and Carbonylation (via Boronic Acids, CH Activation): CO2 Insertion§[3 + 2] Cycloaddition Reaction: Formation of Triazole§Allylic Substitution§Zinc Reagents§Grignard Reagents§Aluminum Reagents§Boron Reagents§Carbene and Nitrene Transfer§Boration Reaction§Boration of Ketone and Aldehyde§Boration of Alkene§Boration of Alkyne§Carboboration§Olefination of Carbonyl Derivatives§Copper-Mediated Cross-Coupling Reaction§Fluoride Chemistry§Other Reactions§A3 Coupling§Semihydrogenation of Alkyne§Borocarboxylation of Alkyne§Hydrocarboxylation of Alkyne§Transmetalation§Conclusion§References§§NHC?AU(I) COMPLEXES: SYNTHESIS, ACTIVATION, AND APPLICAT


Szczegóły: N-Heterocyclic Carbenes

Tytuł: N-Heterocyclic Carbenes
Producent: VCH
ISBN: 9783527334902
Rok produkcji: 2014
Ilość stron: 568
Oprawa: Twarda
Waga: 1.36 kg


Recenzje: N-Heterocyclic Carbenes

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N-Heterocyclic Carbenes

  • Producent: VCH
  • Oprawa: Twarda

This comprehensive reference and handbook covers in depth all major aspects of the use of N-heterocyclic carbene-complexes in organic synthesis: from the theoretical background to characterization, and from cross-coupling reactions to olefin metathesis.§Edited by a leader and experienced scientist in the field of homogeneous catalysis and use of NHCs, this is an essential tool for every academic and industrial synthetic chemist.LIST OF CONTRIBUTORS§PREFACE§§N-HETEROCYCLIC CERBENES§Introduction§Structure and Properties of NHCs§Abnormal Carbenes§Why Are NHCs Stable?§Bonding of NHCs to Metal Centers§Quantifying the Properties of NHCs§Steric Impact§Electronic Properties§N-Heterocyclic Carbenes in the Context of Other Stable Carbenes§Synthesis of NHCs§Salts and Adducts of NHCs§Summary§References§§TUNING AND QUANTIFYING STERIC AND ELECTRONIC EFFECTS OF N-HETEROCYCLIC CARBENES§Introduction§Steric Effects in NHC ligands§Electronic Effects in NHC Ligands§Conclusions§References§§CHIRAL MONODENDATE N-HETEROCYCLIC CARBENE LIGANDS IN ASYMMETRIC CATALYSIS§Introduction§NHC?Ru§Asymmetric Metathesis§Asymmetric Hydrogenation§Asymmetric Hydrosilylation§NHC?Rh§Asymmetric Catalysis Using Boronic Acids as Nucleophiles§Asymmetric Hydrosilylation§Asymmetric Hydroformylation§NHC?Ir§NHC?Ni§NHC?Pd§Asymmetric Intramolecular a-Arylation of Amides§Asymmetric Diamination§Other Asymmetric Catalysis Using NHC?Pd§NHC?Cu§Asymmetric Conjugate Addition§Asymmetric Allylic Substitution§Silyl Conjugate Addition§Enantioselective ß-Boration§Asymmetric Hydrosilylation§Asymmetric Addition to Imines§NHC?Ag§NHC?Au§Enantioselective Cycloisomerizations§Enantioselective Hydrogenation§Enantioselective Cycloaddition§Conclusion§References§§(N-HETEROCYCLIC CARBENE)?PALLADIUM COMPLEXES IN CATALYSIS§Introduction§Cross-Coupling Reactions§Suzuki?Miyaura Coupling§Buchwald?Hartwig Aminations§Negishi Reactions§Hiyama Coupling§Kumada Coupling§Sonogashira Coupling§Heck Reaction§Chelates and Pincer Ligands§Asymmetric Catalysis§Oxidation Reactions§Telomerization, Oligomerization and Polymerization§Anticancer NHC?Pd Complexes§References§§NHC PLATINUM(0) COMPLEXES: UNIQUE CATALYSTS FOR THE HYDROSILYLATION OF ALKENES AND ALKYNES§Introduction§Hydrosilylation of Alkenes: The Beginning§Initial Results with Phosphine Ligands§NHC Platinum(0) Complexes: The Breakthrough§Synthesis of NHC Platinum(0) Complexes and Kinetic Assays§Functional Group Tolerance and Substrate Scope§Mechanistic Studies§Activation Period§Catalyst Deactivation Pathways§Semiquantitative Kinetic Studies§Quantitative Kinetic Modeling§Conclusions§Hydrosilylation of Alkynes§Catalyst Screening and the Impact of NHCs on Regioselectivity§Influence of Silane on Regioselectivity§Second-Generation Catalyst for the Hydrosilylation of Alkynes§Functional Group Tolerance and Substrate Scope§Mechanistic Studies§Qualitative Kinetic Studies§Catalyst Activation and Deactivation Pathways§Proposed Mechanism§Conclusions§References§§SYNTHESIS AND MEDICINAL PROPERTIES OF SILVER?NHC COMPLEXES AND IMIDAZOLIUM SALTS§Introduction§Silver?NHC Complexes as Antimicrobial Agents§Silver?NHC Complexes as Anticancer Agents§Conclusions§References§§MEDICAL APPLICATIONS OF NHC?GOLD AND ?COPPER COMPLEXES§Introduction§Gold Antimicrobial Agents§Metals as Antitumor Reagents§Copper Complexes as Antitumoral Reagents§Conclusion§References§§NHC?COPPER COMPLEXES AND THEIR APPLICATIONS§Introduction§History of NHC?Copper Systems§Hydrosilylation§Allene Formation§1,4-Reduction§Conjugate Addition§Zinc Reagents§Grignard Reagents§Aluminum Reagents§Boron Reagents§Hydrothiolation, Hydroalkoxylation, Hydroamination§Carboxylation and Carbonylation (via Boronic Acids, CH Activation): CO2 Insertion§[3 + 2] Cycloaddition Reaction: Formation of Triazole§Allylic Substitution§Zinc Reagents§Grignard Reagents§Aluminum Reagents§Boron Reagents§Carbene and Nitrene Transfer§Boration Reaction§Boration of Ketone and Aldehyde§Boration of Alkene§Boration of Alkyne§Carboboration§Olefination of Carbonyl Derivatives§Copper-Mediated Cross-Coupling Reaction§Fluoride Chemistry§Other Reactions§A3 Coupling§Semihydrogenation of Alkyne§Borocarboxylation of Alkyne§Hydrocarboxylation of Alkyne§Transmetalation§Conclusion§References§§NHC?AU(I) COMPLEXES: SYNTHESIS, ACTIVATION, AND APPLICAT

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