Concepts and Case Studies in Chemical Biology

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Opis: Concepts and Case Studies in Chemical Biology

Retaining the proven didactic concept of the successful "Chemical Biology - Learning through Case Studies", this sequel features 27 new case studies, reflecting the rapid growth in this interdisciplinary topic over the past few years.§Edited by two of the world's leading researchers in the field, this textbook introduces students and researchers to the modern approaches in chemical biology, as well as important results, and the techniques and methods applied. Each chapter presents a different biological problem taken from everyday lab work, elucidated by an international team of renowned scientists.§With its broad coverage, this is a valuable source of information for students, graduate students, and researchers working on the borderline between chemistry, biology, and biochemistry.Introduction and Preface§Abbreviations§§REAL-TIME AND CONTINUOUS SENSORS OF PROTEIN KINASE ACTIVITY UTILIZING CHELATION-ENHANCED FLUORESCENCE§Introduction§The Biological Problem§The Chemical Approach§Chemical Biological Research/Evaluation§Conclusions§§FLiK AND FLiP: DIRECT BINDING ASSAYS FOR THE IDENTIFICATION OF STABILIZERS OF INACTIVE KINASE AND PHOSPHATASE CONFORMATIONS§Introduction - The Biological Problem§The Chemical Approach§Chemical Biological Research/Evaluation§Conclusions§§STRATEGIES FOR DESIGNING SPECIFIC PROTEIN TYROSINE PHOSPHATASE INHIBITORS AND THEIR INTRACELLULAR ACTIVATION§Introduction - The Biological Problem§The Chemical Approach§Chemical Biological Research/Evaluation§Conclusions§§DESIGN AND APPLICATION OF CHEMICAL PROBES FOR PROTEIN SERINE/THREONINE PHOSPHATASE ACTIVATION§Introduction§The Biological Problem§The Chemical Approach§Chemical Biological Research/Evaluation§Conclusion§§AUTOPHAGY: ASSAYS AND SMALL-MOLECULE MODULATORS§Introduction§The Biological Problem§The Chemical Approach§Chemical Biological Evaluation§Conclusion§§ELUCIDATION OF PROTEIN FUNCTION BY CHEMICAL MODIFICATION§Introduction§The Biological Problem§The Chemical Approach§Biological Research/Evaluation§Conclusion§§INHIBITION OF ONCOGENIC K-Ras SIGNALING BY TARGETING K-Ras-PDEDelta§Introduction§The Biological Problem§The Chemical Approach§Chemical Biological Evaluation§Conclusions§§DEVELOPMENT OF ACYL PROTEIN THIOESTERASE 1 (APT1) INHIBITOR PALMOSTATIN B THAT REVERT UNREGULATED H/N-Ras-SIGNALING§Introduction§The Biological Problem - The Role of APT1 in Ras Signaling§The Chemical Approach§Chemical Biological Research/Evaluation§Conclusions§§FUNCTIONAL ANALYSIS OF HOST-PATHOGEN POSTTRANSLATIONAL MODIFICATION CROSSTALK OF RAB PROTEINS§Introduction§The Biological Problem§The Chemical Approach§Chemical Biological Research/Evaluation§Conclusions§§CHEMICAL BIOLOGY APPROACH TO SUPPRESSION OF STATIN-INDUCED MUSCLE TOXICITY§Introduction§The Biological Problem§The Chemical Approach§Chemical Biological Research/Evaluation§Conclusion§§A TARGET IDENTIFICATION SYSTEM BASED ON MORPHOBASE, CHEMPROTEOBASE, AND PHOTO-CROSS-LINKING BEADS§Introduction§The Biological Problem§The Chemical Approach§Chemical Biological Research/Evaluation§Conclusion§§ACTIVITY-BASED PROTEASOME PROFILING IN MEDICINAL CHEMISTRY AND CHEMICAL BIOLOGY§Introduction§The Biological Problem§The Chemical Approach§Biological Research/Evaluation§Conclusions§§RATIONAL DESIGN OF ACTIVITY-BASED RETAINING BETA-EXOGLUCOSIDASE PROBES§Introduction§The Biological Problem§The Chemical Approach§Biological Research/Evaluation§Conclusions§§MODULATION OF ClpP PROTEASE ACTIVITY: FROM ANTIBIOTICS TO ANTIVIRULENCE§Introduction§The Biological Problem§The Chemical Approach§The Discovery of a Novel Antibiotic Mechanism§The Antivirulence Approach§Conclusions§§AFFINITY-BASED ISOLATION OF MOLECULAR TARGETS OF CLINICALLY USED DRUGS§Introduction - The Biological/Medicinal Problem§The Chemical Approach§Chemical Biological Research§Conclusion§§IDENTIFICATION OF THE TARGETS OF NATURAL-PRODUCT-INSPIRED MITOTIC INHIBITORS§Introduction§The Biological Problem§The Chemical Approach§Chemical Biological Evaluation§Conclusion§§FINDING A NEEDLE IN A HAYSTAY. IDENTIFICATION OF TANKYRASE, A NOVEL THERAPEUTIC TARGET OF THE WNT PATHWAY USING CHEMICAL GENETICS§Introduction§The Biological Problem§The Chemical Approach§Chemical Biological Research/Evaluation§Conclusion§§THE IDENTIFICATION OF THE MOLECULAR RECEPTOR OF THE PLANT HORMONE ABSCISIC ACID§Introduction§The Biological Problem§The Chemical Genetics Approach§The Chemical Biology Approach§Conclusion§§CHEMICAL BIOLOGY IN PLANTS: FINDING NEW CONNECTIONS BETWEEN PATHWAYS USING THE SMALL MOLECULE SORTIN 1§Introduction§The Biological Problem§The Chemical Approach§Biological Research/Evaluation§Conclusion§§SELECTIVE TARGETING OF PROTEIN INTERACTIONS MEDI


Szczegóły: Concepts and Case Studies in Chemical Biology

Tytuł: Concepts and Case Studies in Chemical Biology
Producent: VCH
ISBN: 9783527336111
Rok produkcji: 2014
Ilość stron: 464
Oprawa: Miękka
Waga: 1 kg


Recenzje: Concepts and Case Studies in Chemical Biology

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Concepts and Case Studies in Chemical Biology

  • Producent: VCH
  • Oprawa: Miękka

Retaining the proven didactic concept of the successful "Chemical Biology - Learning through Case Studies", this sequel features 27 new case studies, reflecting the rapid growth in this interdisciplinary topic over the past few years.§Edited by two of the world's leading researchers in the field, this textbook introduces students and researchers to the modern approaches in chemical biology, as well as important results, and the techniques and methods applied. Each chapter presents a different biological problem taken from everyday lab work, elucidated by an international team of renowned scientists.§With its broad coverage, this is a valuable source of information for students, graduate students, and researchers working on the borderline between chemistry, biology, and biochemistry.Introduction and Preface§Abbreviations§§REAL-TIME AND CONTINUOUS SENSORS OF PROTEIN KINASE ACTIVITY UTILIZING CHELATION-ENHANCED FLUORESCENCE§Introduction§The Biological Problem§The Chemical Approach§Chemical Biological Research/Evaluation§Conclusions§§FLiK AND FLiP: DIRECT BINDING ASSAYS FOR THE IDENTIFICATION OF STABILIZERS OF INACTIVE KINASE AND PHOSPHATASE CONFORMATIONS§Introduction - The Biological Problem§The Chemical Approach§Chemical Biological Research/Evaluation§Conclusions§§STRATEGIES FOR DESIGNING SPECIFIC PROTEIN TYROSINE PHOSPHATASE INHIBITORS AND THEIR INTRACELLULAR ACTIVATION§Introduction - The Biological Problem§The Chemical Approach§Chemical Biological Research/Evaluation§Conclusions§§DESIGN AND APPLICATION OF CHEMICAL PROBES FOR PROTEIN SERINE/THREONINE PHOSPHATASE ACTIVATION§Introduction§The Biological Problem§The Chemical Approach§Chemical Biological Research/Evaluation§Conclusion§§AUTOPHAGY: ASSAYS AND SMALL-MOLECULE MODULATORS§Introduction§The Biological Problem§The Chemical Approach§Chemical Biological Evaluation§Conclusion§§ELUCIDATION OF PROTEIN FUNCTION BY CHEMICAL MODIFICATION§Introduction§The Biological Problem§The Chemical Approach§Biological Research/Evaluation§Conclusion§§INHIBITION OF ONCOGENIC K-Ras SIGNALING BY TARGETING K-Ras-PDEDelta§Introduction§The Biological Problem§The Chemical Approach§Chemical Biological Evaluation§Conclusions§§DEVELOPMENT OF ACYL PROTEIN THIOESTERASE 1 (APT1) INHIBITOR PALMOSTATIN B THAT REVERT UNREGULATED H/N-Ras-SIGNALING§Introduction§The Biological Problem - The Role of APT1 in Ras Signaling§The Chemical Approach§Chemical Biological Research/Evaluation§Conclusions§§FUNCTIONAL ANALYSIS OF HOST-PATHOGEN POSTTRANSLATIONAL MODIFICATION CROSSTALK OF RAB PROTEINS§Introduction§The Biological Problem§The Chemical Approach§Chemical Biological Research/Evaluation§Conclusions§§CHEMICAL BIOLOGY APPROACH TO SUPPRESSION OF STATIN-INDUCED MUSCLE TOXICITY§Introduction§The Biological Problem§The Chemical Approach§Chemical Biological Research/Evaluation§Conclusion§§A TARGET IDENTIFICATION SYSTEM BASED ON MORPHOBASE, CHEMPROTEOBASE, AND PHOTO-CROSS-LINKING BEADS§Introduction§The Biological Problem§The Chemical Approach§Chemical Biological Research/Evaluation§Conclusion§§ACTIVITY-BASED PROTEASOME PROFILING IN MEDICINAL CHEMISTRY AND CHEMICAL BIOLOGY§Introduction§The Biological Problem§The Chemical Approach§Biological Research/Evaluation§Conclusions§§RATIONAL DESIGN OF ACTIVITY-BASED RETAINING BETA-EXOGLUCOSIDASE PROBES§Introduction§The Biological Problem§The Chemical Approach§Biological Research/Evaluation§Conclusions§§MODULATION OF ClpP PROTEASE ACTIVITY: FROM ANTIBIOTICS TO ANTIVIRULENCE§Introduction§The Biological Problem§The Chemical Approach§The Discovery of a Novel Antibiotic Mechanism§The Antivirulence Approach§Conclusions§§AFFINITY-BASED ISOLATION OF MOLECULAR TARGETS OF CLINICALLY USED DRUGS§Introduction - The Biological/Medicinal Problem§The Chemical Approach§Chemical Biological Research§Conclusion§§IDENTIFICATION OF THE TARGETS OF NATURAL-PRODUCT-INSPIRED MITOTIC INHIBITORS§Introduction§The Biological Problem§The Chemical Approach§Chemical Biological Evaluation§Conclusion§§FINDING A NEEDLE IN A HAYSTAY. IDENTIFICATION OF TANKYRASE, A NOVEL THERAPEUTIC TARGET OF THE WNT PATHWAY USING CHEMICAL GENETICS§Introduction§The Biological Problem§The Chemical Approach§Chemical Biological Research/Evaluation§Conclusion§§THE IDENTIFICATION OF THE MOLECULAR RECEPTOR OF THE PLANT HORMONE ABSCISIC ACID§Introduction§The Biological Problem§The Chemical Genetics Approach§The Chemical Biology Approach§Conclusion§§CHEMICAL BIOLOGY IN PLANTS: FINDING NEW CONNECTIONS BETWEEN PATHWAYS USING THE SMALL MOLECULE SORTIN 1§Introduction§The Biological Problem§The Chemical Approach§Biological Research/Evaluation§Conclusion§§SELECTIVE TARGETING OF PROTEIN INTERACTIONS MEDI

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