Microcirculatory Effects of Hemoglobin Solutions

  • Producent: Karger
  • Oprawa: Twarda
Wysyłka: Niedostępna
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Opis: Microcirculatory Effects of Hemoglobin Solutions - K Messmer

Solutions of stroma-free hemoglobin have been investigated for their potential as blood replacement fluids for more than 70 years. Despite many attempts to overcome their unwanted side effects through chemical modification of the hemoglobin molecule, none of the potential solutions has been approved for clinical use in Europe or the United States. In recent years, the vasoconstrictive activity of hemoglobin in the plasma was identified as the pivotal problem of hemoglobin-based blood substitutes, compromising nutritional perfusion and thus impeding oxygen unloading at the site of the microcirculation. One of the prevailing assumptions is that the precapillary vasoconstriction and the ensuing tissue underperfusion is caused by the high affinity of free hemoglobin for nitric oxide. To resolve this problem, a number of recombinant techniques involving site-directed mutagenesis as well as several chemical approaches involving polymerization and pegylation have been developed.


Szczegóły: Microcirculatory Effects of Hemoglobin Solutions - K Messmer

Tytuł: Microcirculatory Effects of Hemoglobin Solutions
Autor: K Messmer
Producent: Karger
ISBN: 9783805577199
Rok produkcji: 2003
Ilość stron: 106
Oprawa: Twarda
Waga: 0.38 kg


Recenzje: Microcirculatory Effects of Hemoglobin Solutions - K Messmer

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Microcirculatory Effects of Hemoglobin Solutions

  • Producent: Karger
  • Oprawa: Twarda

Solutions of stroma-free hemoglobin have been investigated for their potential as blood replacement fluids for more than 70 years. Despite many attempts to overcome their unwanted side effects through chemical modification of the hemoglobin molecule, none of the potential solutions has been approved for clinical use in Europe or the United States. In recent years, the vasoconstrictive activity of hemoglobin in the plasma was identified as the pivotal problem of hemoglobin-based blood substitutes, compromising nutritional perfusion and thus impeding oxygen unloading at the site of the microcirculation. One of the prevailing assumptions is that the precapillary vasoconstriction and the ensuing tissue underperfusion is caused by the high affinity of free hemoglobin for nitric oxide. To resolve this problem, a number of recombinant techniques involving site-directed mutagenesis as well as several chemical approaches involving polymerization and pegylation have been developed.

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Cena 310,00 PLN
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