Membrane Structural Biology

This textbook provides a strong foundation and a clear overview for students of membrane biology and an invaluable synthesis of cutting-edge research for working scientists. The text retains its clear and engaging style, providing a solid background in membrane biochemistry, while also incorporating the approaches of biophysics, genetics and cell biology to investigations of membrane structure, function and biogenesis to provide a unique overview of this fast-moving field. A wealth of new high resolution structures of membrane proteins are presented, including the Na/K pump and a receptor-G protein complex, offering exciting insights into how they function. All key tools of current membrane research are described, including detergents and model systems, bioinformatics, protein-folding methodology, crystallography and diffraction, and molecular modeling. This comprehensive and up-to-date text, emphasising the correlations between membrane research and human health, provides a solid foundation for all those working in this field.Dedication; Preface; 1. Introduction; 2. The diversity of membrane lipids; 3. Tools for studying membrane components; 4. Proteins in or at the bilayer; 5. Bundles and barrels; 6. Functions and families; 7. Protein folding and biogenesis; 8. Diffraction and simulation; 9. Membrane enzymes; 10. Membrane receptors; 11. Transporters; 12. Channels; 13. Electron transport and energy transduction; 14. In pursuit of complexity; Appendix I. Abbreviations; Appendix II. Single-letter codes for amino acids; Index.